BG-RESEARCH

International Publication Award Recipients

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Dark sweet cherry (Prunus avium) phenolics enriched in anthocyanins induced apoptosis in MDA-MB-453 breast cancer cells through MAPK-dependent signaling and reduced invasion via Akt and PLCy1 downregulation
Dark sweet cherries (DSCs) are rich source of phenolics known to exert anticancer and anti-invasive activities. This study elucidated the molecular mechanisms underlying the activity of DSC phenolics against MDA-MB-453 breast cancer cells In Vitro. DSC phenolics inhibited MDA-MB-453 breast cancer cells by targeting cell signaling pathways that induce apoptosis and suppress cell invasion, with ACN showing enhanced chemopreventive activities.
Authors:
Marjorie Anne A. Layosa; Nara N. Lage; Boon P. Chew; Liezl Atienza; Susanne Mertens-Talcott; Stephen Talcott; and Giuliana D. Noratto
Published in:
Nutrition and Cancer
doi:
10.1080/01635581.2020.1817514
Date awarded:
May 2021

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